Synthesis, characterization and antimicrobial activity of 1,3,4-thiadiazole bearing 2-phenylacetominophenone derivatives

Author : Birle Rekha, Kayande Nandu, Deshmukh Nitin, Engla Gajanand, Patidar Aarti

In the present study 1,3,4-thiadiazole bearing 2-phenylacetominophenone derivatives were synthesized and antimicrobial activities of different derivatives were checked with various microbial stains. Various intermediates was synthesized and characterized in between time-to-time by chromatographic and spectral methods. Substituted benzaldehyde and sodium cyanide were the starting material and finally formed the 2-phenylacetophenone 2-(1,3,4-Thiadiazole)-2-thiol (e), while in the intermediate steps 1, 2-diphenylethan-1-one (a) reflex with sulphuric acid to get 1,2-diphenylbutane-1,3-dione (b). 1,3,4-Thiadiazole derivative have been synthesize from Schiff base of the corresponding hydrazine by using ethanol with reflex. Then carbon disulfide with potassium hydroxide to give 2-oxa-1, 2 diphenylethylidene 2-hydrazine potassium carbon disulfide (d) and this d finally treated with sulfuric acid to get the title compound. The structures of all the synthesized compound was established on the basic of elemental, chromatographic and spectral analysis. The synthesized compound was evaluated for their antimicrobial activity. The compound most active be against Escherichia coli and staphylococcus aureus.

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