Cubosomes: The next generations of drug delivery in nanoparticles form

Author : Tejaswini B. Desai, Swapnali B. Patil, Omkar B. Tipugade, Shobharaj B. Malavi

Self- assembled lipid liquid crystalline nanoparticles, known as cubosomes. Cubosomes are thermodynamically stable and they have a ‘honey combed’ like appearance. Cubosomes are nanoparticles with proper water-to-microstructure ratios of certain surfactants that have excellent properties. With various drug loading techniques, they show distinct internal cubic structure and composition. They have a greater inner surface area than other carriers, thereby providing the affected cells with more drug molecules and retaining the cubic process, but they have lower viscosity at the same time, thus promoting drug transport. A novel process has been developed for the development of cubic liquid crystalline nanoparticles. Cubosomes have a wide variety of uses in different fields and can be defined by different criteria of assessment. Cubosomes therefore gain more valuable consideration from the pharmaceutical production sector. While no commercial product based on cubosomes is known, most of the research into cubosomes is driven by potential application in drug delivery and material synthesis. Based on the analysis, this study presents cubosomes focusing on their structure, method of preparation, release mechanism, application of cubosomes, advantages and disadvantages.

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