Wound healing potential of Catharanthus Roseus on dead space wound in diabetic rats

Author : Saravanan VS, Manimekalai Pichaivel, Krishnaraju Venkatesan, Kalpana Krishnaraju, Premalatha Paulsamy, Divya Kuppan

Catharanthus roseus L (C.roseus) is a plant that has traditionally been used to treat a wide range of illnesses, including diabetes. The researchers wanted to test if a Catharanthus flower extract might cure streptozotocin induced lesions in diabetic rat. Dead space incisions were made on the diabetic rats axillas. The rats were divided into three treatment groups at random for eight days (Group I: Normal saline; Group II: Diabetic control; Group III: C.roseus). On day 10, the animals were killed, cotton pellets and granuloma tissues were meticulously collected and processed for further analysis. Overall 18 rats were utilised in the experiment. During the trial, the C.roseus group had a substantial increase in dry and wet tissue weight when compared to the other groups. In addition, as compared to the control, C.roseus treatment dramatically enhanced Hydroxy proline, Hexosamines, Hexuronic acid, Tissue protein, and Lysyl oxidase. The increased hydroxyl proline content, as well as other important bio chemicals, support the use of C. roseus for topical wound healing treatment.

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