Triazoles and its pharmacological activities: A Review
Triazole and its derivatives play wide role in drug discovery processes and have considerable chemical significance and biological activities. The triazole derivatives are more than just passive linkers; they readily associate with biological targets, through hydrogen bonding and dipole interactions. In the last years the synthesis of high nitrogen containing heterocyclic nucleus has been attracted to many pharmaceutical industries. Triazole derivatives has a wide range of applications i.e. such as anti-microbial, anti-tumor, anthelmintic, anti-leishmanial, anti-convulsant ,anti-inflammatory, anti-viral, anti-leprotic, anti-depressant, anti-anxiety, antihistamines, antitubercular and analgesic etc. The derivatization of triazole moieties is based on phenomenon of bioisoterism which include replacement of oxygen of oxadiazole nucleus with nitrogen triazole analogue.
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