The effects of Amlodipine plus Losartan combination versus Amlodipine alone on serum uric acid levels in hypertension at a tertiary care hospital of north India

Author : Sharma Nidhi, Agrawal Bimal K, Walia Rani, Sadhotra Akshay

The present study is designed to evaluate the effects of Amlodipine (AMLO) versus Amlodipine plus Losartan (LOS) on serum uric acid (SUA) levels and on other biochemical parameters in hypertension. 60 newly diagnosed hypertensive patients were assigned into two groups randomly. First group (30 patients) were treated with Amlodipine (5mg to 10mg) and Losartan (25mg to 50mg) combination once daily and the second group (30 patients) were treated with Amlodipine (5mg to 10 mg) alone once daily. SUA levels were recorded before the start of treatment, after 6 weeks and after 12 weeks. Statistical analysis was done using paired t test. Out of 30 patients in each group, it was observed that the mean SUA reduction with the combination of AMLO and LOS (14.13%) was more as compared to AMLO alone (10.15%) and this difference is statistically significant (p<0.05). The serum levels of sodium, potassium and urea were same whereas the serum levels of creatinine were decreased from baseline to 12 weeks (3.93% decrease).The serum cholesterol was decreased by 2.43% from baseline to 12 weeks. Both treatments were efficacious in reducing serum uric acid levels but the combination therapy showed greater reduction than monotherapy.

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