The Profile of Macrophage migration inhibitory factor (MIF) and some Immunoglobulins in patients with Autism

Author : Manal M. Kadhim, Abdulzahara M. Saad and Ali S. Shaker

Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD. The present study was conducted to evaluate the role of Macrophage migration inhibitory factor (MIF), and some immunoglobulin (IgG and, IgM) among patients with autism. We have investigated the serum level of MIF, IgG and IgM in 120 subjects. Sixty were autistic patients while others were apparently healthy individuals used as a controls. Of the 60 patients registered 48(80%) of them are male and 12 (20%) female with male to female sex ratio of 4:1. The statistical results indicated higher mean serum concentration of MIF (mean 13.31 ng/ml) versus (mean 5.61ng/ml), but lower mean serum levels of total IgG (20.66 ug/ml) versus (38.01ug/ml) and total IgM (208.18 mg/dl) versus (245.53 mg/dl) in autistic patients than apparently healthy subjects.

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