Synthesis, molecular docking and biological activity of 4-aminoantipyrine dithiocarbamate derivatives

Author : S. Sharada, A.N.V. Sunitha, M. Rupa, O. Navneetha, S. Leemol, T. Saritha Jyostna

In the present investigation, a series of novel 4-aminoantipyrine dithiocarbamates have been synthesized. The synthesized compounds were characterized by IR, 1HNMR, Mass spectral analysis followed by antimicrobial screening. Furthermore, molecular docking studies is an important tool in computational drug design technique, which is employed to understand the mode of binding and binding affinities, it indicates a very good hydrophobic interactions with target receptors.

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