Synthesis, antioxidant activity and QSAR studies of some pyridine derivatives

Author : Ludmila S. Bobkova, Andrew R. Khairulin, Anatoly M. Demchenko, Tatiana A. Bukhtiarova

New quaternary pyridine salts and bases was synthesized and characterized in the presence of iminomethyl-fragment containing the hydroxyl group or the hydroxy-ethyl group or the hydroxyphenyl group with imine nitrogen atom. The synthesized compounds were tested in vitro for an antioxidant activity with a stable radical 2.2-diphenyl-1-picrylhydrazyl and reactivation ability of Sarin-inhibited AChE. The influence of antioxidant activity parameters on reactivation ability and toxicity of the studied compounds was analyzed.

Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at Permissions beyond the scope of this license may be available at