Synthesis, antioxidant activity and QSAR studies of some pyridine derivatives
New quaternary pyridine salts and bases was synthesized and characterized in the presence of iminomethyl-fragment containing the hydroxyl group or the hydroxy-ethyl group or the hydroxyphenyl group with imine nitrogen atom. The synthesized compounds were tested in vitro for an antioxidant activity with a stable radical 2.2-diphenyl-1-picrylhydrazyl and reactivation ability of Sarin-inhibited AChE. The influence of antioxidant activity parameters on reactivation ability and toxicity of the studied compounds was analyzed.
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