Study of the Anti-Anxiety Properties of the Phaseollidin, An Isoflavonoid Isolated from Erythrina droogmansiana (Leguminosae)

Author : Talla Emmanuel, Hadidjatou Dairou, Njapdounke Jacqueline, Nkantchoua Gisèle, Yaya Gbaweng Abel Joël, Ngah Esther, Ngo Bum Elisabeth, Mbafor Tanyi Joseph

The anti-anxiety properties of the phaseollidin, isoflavonoid isolated from Erythrina droogmansiana, were studied in the white mice. Various experimental models (Elevated Plus-Maze, Open-Field, Hole-Board, Hyperthermia Induced Stress), were used to highlight these properties. The results showed that the phaseollidin involved a significant increase of the time spent in the open arms of the raised labyrinth in cross, with 97.8 ± 21.64 seconds for a dose of 50 mg/kg and 115.4 ± 34.03 seconds for the dose 25 mg/kg. These results thus testify to the fall of the aversion of the rodents for enlightened spaces. In the tests of the hole-board and open-field, used to evaluate the exploration and locomotion activities of mice, the results showed a significant increase of the locomotion (crossing) with 42.2 ± 10.30 for the dose 25 mg/kg and 60 ± 9.05 for the dose 100 mg/kg of the phaseollidin. The doses 25 mg/kg and 100 mg/kg of the phaseollidin also showed a significant increase of “rearing”. These results show that the phaseollidin has anti-anxiety properties.

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