Recombinant DNA technology in drug discovery

Author : Dr. Irfan Ahmad Khan

Recombinant DNA (rDNA) technology has made a revolutionary impact in the area of human healthcare by enabling mass production of safe, pure and effective rDNA expression products. Constructing a recombinant DNA molecule involves cutting the DNA into fragments with restriction endonucleases and rejoining the fragments in novel arrangements with ligase. Currently, several categories of rDNA products, viz. hormones of therapeutic interest, haemopoietic growth factors, blood coagulation products, thrombolytic agents, anticoagulants, interferons, interleukins and therapeutic enzymes are being produced using rDNA technology for human use.

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