Possible role of bee pollen dietary supplement in remediation of hepato- and geno-toxic effects of aflatoxins in rats
Background: Mycotoxins are toxic secondary fungal metabolites that implicated in many adverse health effects and economic losses. Recently, bee pollen (BP) has attracted attention as a useful preventive and therapeutic agent referring to its antioxidant properties. Objective: This study aimed to evaluate the potential modulatory effect of BP against aflatoxins (AFs)- induced hepato- and geno- toxicity in rats. Methodology: Twenty four albino rats were randomly divided into four equal groups and treated for 30 days. Control group (fed basal diet); AFs group (3 mg/kg basal diet); BP group (20 g/kg basal diet) and AFs+BP group. Results: AFs in diet induced elevation in serum ALT and AST activities and TC, TG, LDL and VLDL levels with reduction in HDL level. This was associated with increase in hepatic H2O2 with decrease in GSH and NO levels. Furthermore, AFs- induced DNA damage of hepatocytes. Additionally, degeneration, necrosis, and mononuclear cells infiltration were observed in liver of AFs- intoxicated rats. BP supplementation induced a remarkable amelioration of these toxic effects, suggesting its protective antioxidant properties. Conclusion: BP could be used as a biomedicinal supplement in diet to protect animals and humans from hepato- and geno-toxic effects of AFs.
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