Phytochemicals and biological testing of Syzygium guineense seeds extract against Ascaris suum and five pathogenic microbes

Author : Sheila M. Maregesi, Rogers Mwakalukwa, Muhaddisa H. Kassamali

This work is a continuation of our previous study where the crude ethanolic extract of Syzygium guineense seeds demonstrated antihelmintic activity against a non pathogenic worm Pherithema posthuma.The current work aimed at confirmation of antihelmintic activity using the pathogenic worm Ascaris suum, determination of antimicrobial activity and qualitative phytochemical analysis. Antihelminthic activity was confirmed but lower compared to the standard drug Albendazole (API). The extract showed weak to moderate antibacterial and anticandidal activity (MIC values ranging from 0.156 - 1.25 mg/ml) against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 700603), Salmonella typhi (ATCC 6539), and Candida albicans (ATCC 90025). Detected phytochemical compounds were; steroids, terpenes, flavonoids and tannins. Studies to elucidate the phytoconstituents responsible for the exhibited activities and establishment of safety status by using animal models are ongoing.

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