Macrophage migration inhibitory factor and some cytokine gene polymorphism in patient with nephrotic syndrome

Author : Manal M. Khadhim and Shaimaa Audah

Nephrotic syndrome is considered as a multi-factorial clinical condition characterized by increased glomerular permeability with massive consequent proteinuria. There is a variable tendency towards developing edema, hypoalbuminemia and hyperlipidaemia. The present study was conducted to evaluate the role of MIF G173C and TNF-α G308Agenes gene polymorphism in the nephrotic syndrome. We have investigated single nucleotide polymorphisms of MIF G173C and TNF-α G308Agenes in71 subjects. Forty-six were nephrotic patients while others were apparently healthy individuals used as a controls, then the serum level of TNF-α and IL-13 was detected by ELISA technique. The frequencies of MIF C-173C (13.04 vs 4.00%) genotypes and C allele (29.35vs 22.00%)were higher in nephrotic patients than control group while TNF-α A308A(21.74vs 0)genotypes and A allele(38.88vs10%) were significantly higher in patient than control groups and associated with higher mean serum concentration of TNF-α(668.33+27.60) versus (45.64+2.38) and IL-13(36.70+0.55) versus (2.72+0.22),in nephrotic patients than apparently healthy subjects. AA genotype with TNF- α -G308A allele polymorphism and CC genotype with MIF 173C allele are mainly expressed among nephrotic syndrome patients and susceptibility with disease might be prospected.

Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at Permissions beyond the scope of this license may be available at