Article

Influence of cetyl alcohol and enteric polymers on the release of water soluble drug in monolithic bilayered matrix tablet

Author : Sivakumar Vellaichamy, Anbarasi Soundarapandian, Venkateshan Narayanan, Selvaraj Kunjiappan, Rajamanickam Velayutham, Anburaj James

The enteric polymers Eudragit L 100 & Cellulose acetate phthalate was congealed using waxy polymer Cetyl alcohol and their retardant effect of release of diltiazem hydrochloride from the monolithic bilayer tabletwas studied using 23 factorial design. 8 bilayered tablet containing the various polymers at high and low levels were formulated and were evaluated for their physical properties. The influence of the various polymers on the diltiazem hydrochloride release indicated that cetyl alcohol was capable of retarding diltiazem hydrochloride to a higher extent when compared to the polymers Eudragit L 100 and Cellulose acetate phthalate. Further the release of diltiazem hydrochloride from the waxy monolithic matrix was found to have erosion mediated and concentration independent.


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