Formulation development and in-vitro evaluation of elvitegravir loaded solid dispersions to sustained release tablets

Author : Sandhya Banda, G.S. Sharma, B. Rajkamal, B. Rama, L. Jyothi Rani

The aim of the present study is to formulate Sustained release tablets of elvitegravir solid dispersions. The enhancement of oral bioavailability of poorly water soluble drugs like Elvitegravir could be improved by enhancing aqueous solubility. Among numerous ways of enhancing drug dissolution, solid dispersions and inclusion complexation are promising techniques to enhance the dissolution of poorly water soluble drugs. The calibration curve of Elvitegravir was obtained in the range of 2-10 µg/mL at the wavelength of 313 nm. It has shown good linearity with a regression coefficient of 0.999 (r2 value). This result exhibit a direct relationship between concentration of polymers and drug release. Among the various formulations tablets of batch E2 prepared with 40mg Guar gum showed complete release of drug within 24 hrs.

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