Formulation, development and evaluation of oil entrapped calcium alginate floating beads of atenolol for antihypertensive drug

Author : Shivendra Agarwal, Raghvendra Misra, Aashish Kumar Verma, Prabhakar Vishvkarma, Amit Saxena

Atenolol, a competitive beta (1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract.The elimination half-life of atenolol is up to 6 to 7 hours. The oral doses of 50 mg or 100 mg both b-blocking and anti-hypertensive effects persist for at least 24 hours. In the present work an attempt has been made to prepare oil entrapped floating calcium alginate beads containing Atenolol to target the drug to stomach mucosa for prolonged period of time. Beads were prepared by using sodium alginate, mustard oil, olive oil and prepared by using emulsion gelation technique to improve gastric retention. The prepared beads were evaluated for physical characterization floating lag time, total floating time, swelling index and in vitro drug release studies. The prepared beads were found to be spherical, free flowing and remain buoyant for 24 hrs with a short floating lag time. It was found that the cumulative drug release from all formulations was found to be between 91.74 to 99.042.

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