Formulation and in vitro evaluation of sustained release tablets of aceclofenac

Author : Srijan Shrestha, Shrawani Lamichhane, Aastha Shrestha, Junu Khatri Silwal, Bhupendra Kumar Poudel and Pradeep Paudel

The present work is based in designing sustained release Aceclofenac tablets that could be given once daily for the symptomatic treatment of pain and inflammation. Hydrophilic matrix Aceclofenac tablets by direct compression were formulated with HPMC K4M and HPMC K100M in the concentration of 6%, 9% and 11%. A total of such six formulations were analyzed in terms of pre-compresion and post compression parameters. They were then compared with marketed products in terms of dissolution. The results revealed that drug release decreases with increase in viscosity of polymer and on increasing polymer concentration, the dissolution retards. The dissolution of formulated tablets showed good similarity and difference factor with marketed products. The formulation with highest similarity factor and lowest difference factor was chosen as an optimized formulation and the correlation of dissolution of marketed product with optimized formulation was carried which showed good correlation with R2=0.961. The drug release was fitted in different mathematical models to study model dependent analysis which showed that most formulations followed Higuchi model, some followed peppas and some zero order. Therefore, sustained release Aceclofenac tablets prepared using HPMC K100M could be the best rather than HPMC K4M for its sustaining actions.

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