Article

Formulation and evaluation of fast dissolving tablets of ketoprofen

Author : S. Muralidhar, T.V. Narayana, Ch. Phani kumar, Mahajan Anil Arun

Ketoprofen is non-steroidal anti-inflammatory drug mainly used for osteoarthritis and rheumatoid arthritis. The major problem with this drug is its very low solubility in biological fluids which results in poor solubility after oral administration. Therefore solid dispersion of Ketoprofen with PEG-6000 and PVP K30 in different weight ratios were prepared with a view to increase it’s water solubility. The solid dispersions were evaluated by solubility study, drug content, in-vitro drug release study, dissolution efficiency and characterized by FT-IR. The Ketoprofen SD with PVP K30 (1:3) ratio showed maximum amount of drug release hence it was selected for Fast Dissolving Tablet formulation. The Fast Dissolving Tablets of Ketoprofen were prepared by direct compression technique by addition of different concentrations of superdisintigrants like Sodium starch glycolate, Crosscarmalose sodium and Crospovidone, The prepared tablets were evaluated for Pre- Compression and Post- Compression Parameters among all the formulations F15 showed least disintegration time and % drug release. Stability study of F15 was carried out at 400c and 75% RH for three months. Stability study confirms there is no significant change in the formulation of F15.


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