Formulation and Evaluation of Fast Disintegrating Sublingual Tablets of Rizatriptin Using Different Superdisintegrants

Author : Lakshmi Usha Ayalasomayajula, Radha Rani Earle, B. Sadhana, L. Divya Sri

The aim of present study was to design and evaluate fast disintegrating sublingual tablets of Rizatriptan using different super-disintegrants. Migraine is a common type of headache that may occur with symptoms such as nausea, vomiting or sensitivity to light. In many people, a throbbing pain is felt only on one side of the head. The oral dispersible dosage forms are less effective as they undergoes first pass metabolism. Compared with ODT, the onset of action produced by sublingual tablets is faster. Rizatriptan is one of the widely used drugs for the treatment of migraine. The objective of the present study was to develop fast disintegrating sublingual tablets of Rizatriptan using different superdisintegrants like croscarmellose sodium, crospovidone and L-HPC in different concentrations. The tablets were evaluated for pre compression and post compression parameters. Among all the formulations, F3 was selected as best formulation and stability studies of the prepared tablets (F3) were performed at certain conditions as per ICH guidelines.

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