Extractive visible spectrophotometric determination of naftopidil in pharmaceutical preparations

Author : K. Raghubabu, K. Sandhyarani, M. Srividhya

A simple, sensitive, rapid and accurate extractive visible spectrophotometric method has been developed for the determination of Naftopidil in pure and in pharmaceutical formulations. The method is based on the formation of orange red colored chloroform extractable ion‐pair complex between the basic nitrogen of the drug and acidic dye Tropaelin ooo (TPOOO) in the presence of 0.1M HCl with an absorption maximum of 502.0 nm.The conditions necessary for the assaying the drug are established. The calibration graph is linear over the concentration range of 4-24μg/ml. The proposed method is applied to commercial available tablets or capsules and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The method offers the advantages of rapidity, simplicity and sensitivity and low cost and can be easily applied to resource poor settings without the need for expensive instrumentation and reagents.

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