Enhancement of solubility and dissolution rate of glibenclamide using poloxamer 407 as carrier

Author : Ramanpreet Kaur, Sandeep Kumar

The purpose of present study is to increase the solubility and dissolution rate of Glibenclamide, a poorly water soluble drug by lyophilization technique using a hydrophilic carrier, poloxamer-407. The prepared lyophilization product showed an enhancement in solubility and dissolution rate. Lyophilized products were characterized with Infrared spectroscopy, X-ray diffraction and scanning electron microscopy. These techniques revealed that increase in solubility and dissolution rate of glibenclamide is due to decrease in crystallinity of the drug. In conclusion formulation of glibenclamide lyophilized product with water soluble polymer could be a suitable approach to improve solubility and dissolution rate of glibenclamide.

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