Drug design and synthesis of 1, 3, 4-oxadiazolo cinnoline analogs as potent antitubercular agents

Author : Hurmath Unnissa S, RaviT.K and Sonia George

A Series of 3-(5-substituted-1,3,4-oxadiazol-2-yl)-6-substitutedcinnolin-4-ol and 5-(4-hydroxy-6-substitutedcinnolin-3-yl)-1,3,4-oxadiazole-2(3)-thione were synthesized from 4-hydroxy-6-substitutedcinnoline-3-carbohydrazide. The structures of the newly synthesized compounds were confirmed by IR, NMR, Mass and elemental analysis. All the designed leads were optimised for ADMET parameters to predict drug likeliness using QIKPROP [GLIDE]. All the compounds were screened for their antibacterial and antifungal activity against various pathogenic microbes. Some of the compounds displayed very good antibacterial and antifungal activity remaining compounds showed moderate to good activity.

Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at Permissions beyond the scope of this license may be available at