Design, development and evaluation of pulsatile drug delivery system using tablet in tablet formulation

Author : Swati Mittal, Kawale Sandip, John Jobin

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study was carried out by USP type II (paddle) apparatus. Initially, drug release was slow for 3-6 hr followed by a burst release. Lag time of tablet increased with increasing viscosity of the HPC and load of outer shell. However, the compression load had little effect.

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