Chlorogenic acid, a polyphenolic compound, ameliorated haloperidol-induced orofacial dyskinesia and catalepsy in rats
Chlorogenic acid, a polyphenolic bioactive compound, has been reported to possess protective effect against reserpine-induced orofacial dyskinesia in rats, but the effect of chlorogenic acid on haloperidol-induced orofacial dyskinesia has not been reported in the literature. Therefore, the aim of the current study was to investigate the effect of chlorogenic acid on haloperidol-induced orofacial dyskinesia and catalepsy in Wistar male albino rats. Haloperidol (1 mg/kg) was injected by intraperitoneal route to rats for 21 consecutive days to induce orofacial dyskinesia and catalepsy. Chlorogenic acid (10, 20 and 40 mg/kg) was administered orally 45 min prior to haloperidol administration to separate groups of rats for 21 consecutive days. Haloperidol significantly increased vacuous chewing movements (VCMs) and tongue protrusions in rats, indicating induction of orofacial dyskinesia. It also increased catalepsy time and decreased locomotor activity of rats. Haloperidol-induced VCMs, tongue protrusions, catalepsy and hypolocomotion were significantly ameliorated by chlorogenic acid. Haloperidol significantly decreased brain dopamine and serotonin levels which were significantly restored by chlorogenic acid administration. The results of present study indicated significant protective effect of chlorogenic acid against haloperidol-induced orofacial dyskinesia and catalepsy, probably through increase in brain dopamine and serotonin levels.
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