Antioxidant and antimicrobial evaluation of pyrimido [1, 2-a] benzimidazoles

Author : S. P. Vartale, P. N. Ubale, S. G. Sontakke, N. K. Halikar and M. M. Pund

When ethyl 2-cyano-3,3-bis(methylthio)acrylate (2) on treatment with 2-amino benzimidazole (1) in N,N-dimethyl formamide (DMF) and catalytic amount of anhydrous potassium carbonate, gives 3-cyano-2-metylthio-4-oxo-4H- pyrimido [1,2-a] benzimidazole (3).The latter were further reacted with selected N-,O- and C- nucleophiles such as aryl amines, heteryl amines, substituted phenols and compounds containing an active methylene group to afforded 2-cyano-3-metylthio-4-oxo-4H-pyrimido [1,2-a] benzimidazole and their 2-substituted derivatives. All newly synthesized compounds were evaluated and characterized by spectroscopic techniques and screened their very excellent antioxidant and antimicrobial activities.

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