A comparative study to evaluate efficacy & safety of topical monotherapy with tazarotene & calcitriol versus their topical sequential treatment in chronic stable plaque psoriasis

Author : Kavita Dhar Bagati, Meeta Kaushik, V. S. Chopra and Neerjesh

Psoriasis is a chronic and recurring, multi-system inflammatory disease characterised by scaly, painful and disfiguring skin lesions. Stable plaque psoriasis is the most common form, affecting 80-90% of the patients. Aim of this study is to compare the safety and efficacy of the Topical sequential therapy with Tazarotene and Calcitriol with their monotherapies in stable plaque psoriasis. Total no. of 120 patients having more than 18 years of age with lesions of more than 3 months was included. 4 groups of pts were given different drug regimen upto 4 & 8 wks. It was concluded that topical treatment with tazarotene and calcitriol are efficacious in the treatment of mild to moderate stable plaque psoriasis as both sequential and monotherapy. Although, topical treatment with calcitriol as monotherapy is far more efficacious and safe than monotherapy and sequential therapy with tazarotene. Also, calcitriol has better patient acceptability than tazarotene.

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