Mangifera indica is a plant used in traditional medicine in the West region of Cameroon. This study aimed to assess the toxicity profile of the aqueous extract of Mangifera indica (AEMI) stem bark. The extract was tested on larvae of Artemia salina for cytotoxicity study and in rats for acute and sub-chronic oral toxicity studies. For acute evaluation, AEMI was given to rats at single dose of 5000 mg/kg and they were observed for 14 days. For sub-chronic study, AEMI was administered at doses of 300, 400 and 500 mg/kg for 28 days; body weight, food and water intake, hematological, biochemical and histological parameters were evaluated. The results showed that AEMI has no cytotoxic effect and the mean lethal concentration (LC50) was 4168 μg/mL. No mortality or signs of toxicity were observed in the acute study. In the subchronic study, water consumption, serum AST, triglycerides, total and LDL cholesterol significantly decreased (p<0.05) whereas platelets count, urinary volume, serum creatinine and HDL cholesterol significantly increased (p<0.05). Histopathological analysis revealed some abnormalities on the livers and kidneys of rats treated at dose of 500 mg/kg. The results suggest that AEMI may have deleterious effects at high doses following long term administration

Keywords : Mangifera indica; cytotoxicity; acute toxicity; sub-chronic toxicity

Author : Tchoumba Tchoumi LM, Poualeu Kamani SL, Miaffo D, Nchouwet ML, Yousseu Nana W, Wego Kamgaing MT, Kamanyi A, Wansi Ngnokam SL

Title : Toxicological profile of the aqueous extract of Mangifera indica Linn (Anarcadiaceae)

Volume/Issue : 2020;8(3)

Page No : 49-60

Objective: To investigate the level of awareness about sources and benefits of Monoclonal anti-Bodies among medical students. Monoclonal anti-bodies are the immunoglobulin that is produced from clones of B- cells i.e. their parent cells. Methods: A cross-sectional survey of medical students aged 20-30 years from the different universities of Karachi selected by convenient sampling method, conducted from august to September 2019. Data was collected through a self-administered questionnaire. Results: We have carried out a survey among medical students regarding their awareness, on mono clonal anti-bodies and 300 responses were collected approximately, these antibodies are used for different purposes such as, cancers, auto immune diseases and cardio vascular diseases. Further, these mAb are preferred for their easiness in measuring and are highly reproducible. Conclusion: From the results of our survey we concluded that majority of the students were aware about what are mAb, their uses, advantages and from what sources they are derived from.

Keywords : Monoclonal antibodies, vascular diseases, immunoglobulin, survey

Author : Samina Alam, Huma Dilshad, Jamila Khatoon Qasmi, Syeda Arshmah Imran, Aisha Minhal, Sobia Shafqat, Syeda Ailiya Zaidi, Saima Alam, Irfan Alam

Title : Perspective and awareness about sources and benefits of Monoclonal Anti-Bodies among medical students

Volume/Issue : 2020;8(3)

Page No : 61-64

The Gomm-Button disease/Sweet’s syndrome is a rare and reactive disorder so often idiopathic, sometimes associated with diseases and drugs rarely. Herein, we report a case of a 49 year old female patient, presented to the dermatology department with a 3 day history of low grade fever and 1 day history from congestion of eyes, along with development of multiple itchy and painful bullous vesicular skin lesions distributed over face and upper limbs. Lab Examination revealed elevated white blood cells and negative IgE. Histopathological and cytology reports showed neutrophilic infiltrates which were suggestive of Gomm-Button disease.

Keywords : Sweet’s syndrome, acute febrile dermatosis, Acetaminophen, Drug Induced Sweet Syndrome (DISS)

Author : P. Joise, S. Soniya, S. Christopher, P. Jennet

Title : Case report on Acetaminophen induced Gomm - Button disease

Volume/Issue : 2020;8(3)

Page No : 65-69

Garbhini awastha is a precious phase in women's life. This phase should not be risky both for mother and child that’s why extra care needs to be taken during pregnancy. To assure a safe motherhood as well as healthy progeny Ayurveda has given prime importance to ante-natal care and elaborated it as 'Garbhini Paricharya' by many acharya's. According to WHO, it suggests that everyday around 800 women die due to complications related to pregnancy and child birth. To minimise this rate, Garbhini paricharya is the need of the era.

Keywords : Sukha Prasava, Garbhini, Antenatal care, Healthy progeny

Author : Dr. Nayana Ramkumar Kharade and Dr. Varsha Suresh Deshmukh

Title : A review on nutritional requirements throughout pregnancy w.s.r. Garbhini Paricharya

Volume/Issue : 2020;8(3)

Page No : 70-73

In living cells, biosimilars are produced and are usually large, complex proteins that can have a variety of uses. Biologics are used in the field of gastroenterology alone for treating inflammatory bowel diseases, tumors, and endocrine disorders. Biosimilar development is an attempt to reduce the cost of the treatment. Currently, seven biosimilars have been approved by the United States Food and Drug Administration (FDA) for use in Crohn’s disease, ulcerative colitis, and colorectal cancer. There are other biologics involved in treating gastroenterologic diseases for which there are no FDA approved biosimilars. The overview of the article explains the use of biosimilars in the treatment of IBD, Oncology, Diabetics, breast cancer.

Keywords : Biosimilars, Treatment, Disease

Author : Sridhar Siddiraju, Divya Srirambhatla

Title : A short review on biosimilars: Future treatment method

Volume/Issue : 2020;8(3)

Page No : 74-78