Mangifera indica Linn (Family: Anacardiaceae), commonly known as mango widely used in the traditional medicinal system. This study is performed to gain information by molecular docking of seven isolated compounds of M. indica that are responsible for anti-diabetic activity by promoting insulin. Molecular docking was done by Schrodinger, whereas the SwissADME and admetSAR were used for ADME and toxicological prediction. In molecular docking study, Gallic acid (-6.345kcal/mol)showed the highest docking scores where all compounds satisfied Lipinski’s rule of five while without one, all other compounds showed non-toxicological properties. This study evidentthat isolated compounds possesses significant anti-diabetic properties, which might be beneficial in the treatment of diabetes mellitus.

Keywords : Anti-diabetic, Mangifera indica, Mango, Medicinal plants

Author : Md. Mohotasin Hossain, Abu Montakim Tareq and Yeasir Abid

Title : Experimental analysis of isolated compounds of Mango (Mangifera indica L.)Seed Kernel Extract for promoting insulin against diabetes mellitus by using computational analysis

Volume/Issue : 2019;7(12)

Page No : 99-105

The aim of the study is to assess and attenuate the risk of stroke in diabetes mellitus, dyslipidemia and hypertensive patients. The main objective is to assess the risk of stroke in diabetes mellitus, dyslipidemia and hypertensive patients. The prospective interventional study was conducted in the department of general medicine at PSG IMSR medical college, Coimbatore for a period of 6 months. Total 150 stroke patients were recruited in the study based on inclusion and exclusion criteria and were analyzed. Based on the interview, 17 patients were having the history of hypertension, 35 patients were known case of diabetes mellitus and there were 2 dyslipidemic patients. From this study it was concluded that males are more prone to risk of stroke than females. The outcome of this study will reduce or modify risk factors associated with stroke in study participants. It may create effective awareness regarding management of risk factors.

Keywords : Stroke, hypertension, diabetes mellitus, dyslipidemia, patient counselling

Author : Mohamed Thoufiq Ilahi and Kavitha P

Title : Assessment and attenuation of risk of stroke in diabetes mellitus, dyslipidemia and hypertensive patients

Volume/Issue : 2019;7(12)

Page No : 106-112

A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in pure and tablet dosage form. The spectra of Telmisartan in tri ethyl amine, methanol, distilled water in ratios of 5:10:85, v/v/v shows λmax at 297 nm and estimation was carried out by comparison with standard. Calibration graph was found to be linear (r2= 0.999) over the concentration range of 10-50 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted for the estimation of telmisartan in its routine analysis.

Keywords : Telmisartan, UV Spectrophotometry, Calibration curve, Validation

Author : Ramya Nagabathula, G. Madhuri, U. Rama Devi, A. Vamsi, K. Bhavani

Title : UV Spectroscopic method for estimation and validation of Telmisartan in bulk and tablet dosage forms

Volume/Issue : 2019;7(12)

Page No : 113-117