Anaemia is a major public Health problem in India. In our Country, nearly three quarters of the population live in rural areas, the epidemiology of anaemia in rural settings is not well known. We performed a observational study using Routine Clinical data from patients attending the out-patient clinics of a Hospital. Totally 100 samples were collected. 83 of patients were females and 17 patients were males. The Result of the study shows that 3 patients in females and 4 patients in males having the Haemoglobin level of (>1-5) g/dL. Also 80 females and 13 males showing the Haemoglobin level of (<1-5)g/dL. These shows while mild to moderate anaemia were more common in male patients as compared to female patients.

Keywords : Anemia, Iron Deficiency Anaemia, Haemoglobin, WHO

Author : DuraiRajan P , Sujitha M, Vijayalakshmi C. S

Title : Prevalence of Anaemia in Tertiary Care Hospital

Volume/Issue : 2018;6(10)

Page No : 1-4

The objective of the present study was focused phytochemical screening of Dodonia viscosa (DV) Versatile medicinal plant. The arial parts of DV was subjected to the super critical fluid extraction (SCFE) and confirmed for the presence of many phytoconstituents like flavonoids, glycosides, saponins etc. Further the procured extract was subjected to column chromatography and isolated the active bio-compounds, those were subjected for antioxidant activity by following DPPH and SOD method. Antineoplastic activity was carried out against Erlichs Ascites Carcinoma (EAC)-induced mice. The extract and isolated bio compound showed good antioxidant and anticancer activity, however further investigations of MTT-assay is required for structural elucidation of bioactive compounds.

Keywords : SCFC, EAC, Dodonaeaviscose, DPPH, SOD

Author : A.M. Krupanidhi, Prakash Dabadi, Jayamma Kulkarni, Darshan Ekbote and Prasd Davan

Title : Anti-neoplastic activities of targeted bio- moieties of Dodonaea Viscosa

Volume/Issue : 2018;6(10)

Page No : 5-13

Tuberculosis is an infectious disease caused by the bacilli Mycobacterium tuberculosis. It commonly affects the lungs, pulmonary TB but can also affect other sites, extra pulmonary TB. A male patient of age 74yrs was admitted on emergency with complaints of continuous GTCS of 20-25 episodes without regaining of consciousness with history of Anti Tubercular Therapy for 8 months. Trabeculoma induced seizures was confirmed by radiologic investigation and similar report. The drugs are selected based on its efficacy. Here, T. Phenytoin 100mg twice daily, T. Lacosamide 100mg twice daily, T. Levetiracetam 750mg twice daily was given for treating the patient. Even though the seizure was induced by the formation of trabeculoma, antiepileptic drugs were given to the patient to prevent seizure recurrence.

Keywords : Mycobacterium,b Trabaculoma, Epilepsy

Author : Dr. Vishnu Das

Title : Trabeculoma Induced Epilepsy: A Case Study

Volume/Issue : 2018;6(10)

Page No : 14-16

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. It can also be used as starting material for other bioactive molecules. This review provides an overview of the synthesis and pharmacological activities of Benzoxazole nucleus such as antimicrobial, anticonvulsant, anti-inflammatory, anticancer, anti-tubercular, antidepressant, anti- helminthic and miscellaneous activities.

Keywords : Benzoxazole, synthesis, pharmacological activities

Author : Ankita Pasricha, SharadWakode, FaizanaFayaz, ChitwanChhabra

Title : Benzoxazoles: A mini review

Volume/Issue : 2018;6(10)

Page No : 17-24

Surgical site infection is the greatest enemy to the success of a surgeon which is a dreaded complication that can result in poor outcomes, increased morbidity, prolonged hospital stay, escalation of hospital expenditure and mainly constrained relationship between the patient and the surgeon, placing an immense economic burden on the patient and the healthcare infrastructure. The origin of SSI is multifactorial, where Bacteria may get access to the surgical site through both endogenous and exogenous routes, predominantly exogenous contact during the first operative exposure. Staphylococcus aureus is the leading cause of SSI. Implants give a niche for such organisms where biofilms offer a safe environment for their replication. Various modifiable risk factors are also there such as DM, Obesity, Malnutrition etc. The goal of this study was to find out whether nasal carriage of Staphylococcus aureus is a major risk factor for surgical site infection in orthopaedic surgery

Keywords : Surgical site infection, Staphylococcus, Diabetes Mellitus

Author : Sana Raphael, Lincy George and K. Krishnakumar

Title : Nasal carriage of staphylococcus aureus is a major risk factor for surgical-site infections in orthopedic surgery: A review

Volume/Issue : 2018;6(10)

Page No : 25-29

Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. Niosomes are formations of vesicles by hydrating mixture of cholesterol and nonionic surfactants. It can be used as carriers of amphiphilic and lipophilic drug. In niosomes drug delivery system, the medication is encapsulated in a vesicle. Niosomes are biodegradable, biocompatible, and non-immunogenic and exhibit flexibility in their structural characterization. The main object of this review the application of niosomes technology is used to treat a number of diseases, niosomes have good opportunity in research and beneficial for researcher and pharma industries. Niosomes appears to be a well preferred drug delivery system over liposome as niosomes being stable and economic. Also niosomes have great drug delivery potential for targeted delivery of anti-cancer, anti-infective agents. Drug delivery potential of niosomes can enhances by using novel drug delivery concepts like pro-niosomes, discomes and aspasome. Niosomes also serve better aid in diagnostic imaging and as a vaccine adjuvant. Thus these areas need further exploration and research so as to bring out or to make for commercially available niosomal preparation.

Keywords : Niosomes, Pronoisome, Non-ionic surfactant, Cholesterol

Author : Kothare Ashwini, Bhaskar Payal, Rane Pritishikha, Gavhane Mayuri, Kad Dhanashree

Title : Niosomes: A Versatile Drug Delivery System

Volume/Issue : 2018;6(10)

Page No : 30-39

The ethnobotanical survey conducted in Zou and Colline regions in February 2015 yielded twelve plants used traditionally against high blood pressure (hypertension) by the local population.. The phytochemical analysis and the biological screnning allowed to identify two plants more active (Carissa eduliss Apocynaceae, Diodiascandess Rubiaceae) than the active plant identified during a previous biological screnning carried out in 2006 [1]. These two active plants are very rich in phenolic compounds and have the same phytochemical profile in contrast to the others plants which have different phytochemical profile. The active plants have an antioxidant activity closer to that of the standards used. Some plants of the sample have a very strong antioxidant activity but are not active. The vasorelaxant activity of these two plants (Carissa edulis Apocynaceae, Diodia scandess Rubiaceae) is superior to the vasorelexant activity of Parkia biglobosa (Mimosaceae) [1]. Through this study, two new plants traditionally used against hypertension are retained among the twelve selected plants.

Keywords : Medicinal plants, arterial hypertension,vasorelaxant activity

Author : Jean-Marie Tokoudagba; Clément D. Gandonou; Ursula Houngue; Cyril Auger; Valerie B. Schini-Kerth

Title : Phytochemistry and Vasorelaxant activity of some plants used traditionnaly against high blood pressure in Benin

Volume/Issue : 2018;6(10)

Page No : 40-48

Abnormal activation or silencing of mitogen activated protein kinase (MAPK) pathways, protein kinase C (PKC) and phosphatidyl inositol -3- kinase (PI3k) result in uncontrollable cell growth which leads to translation of normal cells to cancer cells. Many phytochemical chemo preventive agents are capable of controlling these enzymes and preventing abnormal cell growth and proliferation. Diets rich in fruits and vegetables are gaining increased importance due to their significant role in reducing the risk of degenerative diseases such as cancer, cardiovascular diseases and other chronic diseases. This review summarize current information on different groups of dietary antioxidants and their possible role in chemo-prevention of most important human cancers.

Keywords : Free radicals, Dietary antioxidants, Chemo preventive agents

Author : Jisha Prems, Jiji Jose, Reshma PT

Title : Dietary Antioxidants: True Fighters against Oxidative Stress Induced Cancer

Volume/Issue : 2018;6(10)

Page No : 49-56